Chemical Biology and Cancer Drug Discovery Laboratory
We use and develop covalent and non-covalent small molecules, hetero-bifunctional degraders, and molecular glues to disrupt protein-protein or protein-DNA interactions of challenging protein targets (also known as undruggable) in cancer and cancer immunotherapy. We are interested in RAS and Rho GTPases, TEAD and ETS transcription factors, uPAR, and HPV E6/E7 oncogenes. We are also using uPAR small molecules developed in our lab for drug delivery, gene therapy, and membrane protein degradation strategies in solid tumors.
If you are interested in joining us on this journey, please email me at smeroueh@illinois.edu. There are several openings for student and postdoc positions in my laboratory.