Chemical Biology and Cancer Drug Discovery Laboratory
We develop small molecules to explore protein-protein and protein-DNA interactions of previously undruggable Rho/RAS GTPases and transcription factors. We follow a fragment-based drug design strategy to develop small-molecule covalent and non-covalent inhibitors, molecular glues, and heterobifunctional degraders. Small molecules provide us with chemical tools and lead compounds to investigate proteins of interest in cancer and immune system cells, as well as in animal models of inflammation and cancer.
If you are interested in joining us, please email me at smeroueh@illinois.edu.