Chemical Biology and Cancer Drug Discovery Laboratory

We develop covalent and non-covalent small molecules, hetero-bifunctional proteolysis-targeting chimeras (PROTACs), and lysosome-targeting chimeras (LYTACs) to modulate the function of unexplored or challenging protein targets in cancer and cancer immunotherapy. We use a fragment-based screening approach to identify new reaction and binding sites on these proteins. Fragments provide a foundation to develop small molecules that we use to explore targets in cancer cells and animal models. We are interested in RAS and Rho GTPases, TEAD and ETS transcription factors, cell-surface protein uPAR, and HPV E6/E7 oncogenes.

If you are interested in joining us on this journey, please email me at smeroueh@illinois.edu. There are several openings for student and postdoc positions in my laboratory.