Chemical Biology and Medicinal Chemistry Laboratory in Cancer and Immunity
We develop and use small molecules to disrupt or stabilize protein-protein and protein-DNA/RNA interactions of undruggable Rho/RAS GTPases and transcription factors of the TEAD and ETS families. We follow a fragment-based drug design strategy to develop covalent and non-covalent inhibitors, molecular glues, and heterobifunctional degraders. Small molecules provide us with chemical tools and lead compounds to investigate proteins of interest in immune and cancer cells.
If you are interested in joining us, please email me at smeroueh@illinois.edu.