Chemical Biology and Cancer Drug Discovery Laboratory
We develop small molecules to explore previously undruggable Rho/RAS GTPases and transcription factors in cancer and immune system cells. We follow a fragment-based drug design strategy to develop covalent, molecular glue, and heterobifunctional small-molecule degraders, inhibitors and activators. Small molecules provide us with chemical tools and lead compounds to investigate proteins of interest in animal models of inflammation, cancer, and injuries of the central nervous system.
If you are interested in joining us, please email me at smeroueh@illinois.edu.